#Cad disease pdf
Prevalence of uncontrolled risk factors for cardiovascular disease: United States, 1999–2010 pdf icon. Heart disease and stroke statistics-2021 update: a report from the American Heart Association external icon. Virani SS, Alonso A, Aparicio HJ, Benjamin EJ, Bittencourt MS, Callaway CW, et al.Atlanta, GA: Centers for Disease Control and Prevention 2018. Centers for Disease Control and Prevention.National Heart, Lung, and Blood Institute external icon.American Heart Association external icon.State Public Health Actions to Prevent and Control Chronic Diseases.Several other medical conditions and lifestyle choices can also put people at a higher risk for heart disease, including:ĬDC Public Health Efforts Related to Heart Disease High blood pressure, high blood cholesterol, and smoking are key risk factors for heart disease. When it does, a blood clot can form on the plaque, blocking the flow of blood. Sanofi Genzyme is committed to transforming the care of people living with rare blood disorders.As plaque builds up in the arteries of a person with heart disease, the inside of the arteries begins to narrow, which lessens or blocks the flow of blood. Research is being done every day to find more answers for people living with this rare condition. Though researchers are getting closer, there are currently no treatments approved specifically for cold agglutinin disease. Additionally, patients with CAD are also at risk of experiencing sudden drops in their hemoglobin that may require emergency treatment. A 10-year review of the medical histories of people with CAD showed that they had a higher risk of stroke, heart attack, or blood clots. Recent studies have shown that CAD may be more serious than previously thought. If your organs and tissues don’t get enough oxygen, they can’t function normally-making you feel tired. That’s because red blood cells are destroyed prematurely and are not able to do the vital job of carrying oxygen throughout your body. It can cause anemia, along with severe fatigue. In people with CAD, the destruction of red blood cells, or C1-activated hemolysis, is happening all the time. At the end of the pathway, the marked cell is destroyed.This leads to a complex chain of events that marks the red blood cell for destruction The pathway starts with a protein called C1 binding to the red blood cell.The cold agglutinin antibody mistakenly attaches to a red blood cell and activates the complement pathway.This activation results in the constant destruction of red blood cells, known as hemolysis. In cold agglutinin disease, certain abnormal bone marrow cells produce antibodies called cold agglutinins, which activate a part of the immune system known as the complement pathway. It’s a form of autoimmune hemolytic anemia, which means the immune system mistakenly attacks and destroys red blood cells. Sign Up Now Let’s take a closer look at the immune system and the complement pathway.Ĭold agglutinin disease (CAD) is a rare, severe blood disorder. Sign up to learn more about what’s happening in your body, or to receive additional education and resources. When you have CAD, and red blood cells are destroyed prematurely, they are not able to do the vital job of carrying oxygen throughout your body. Even if you’re not continuously exposed to the cold, the ongoing hemolysis could lead to complications like anemia, a lack of red blood cells or hemoglobin in the blood that can cause severe fatigue. This activation results in ongoing, constant destruction of red blood cells (hemolysis). If you’re living with cold agglutinin disease, certain abnormal bone marrow cells (called cold agglutinins) activate a part of your immune system known as the complement pathway. When this happens, it’s called Cold Agglutinin Syndrome (or CAS).Īnemia occurs when you do not have enough red blood cells or when your red blood cells do not function properly In some people, cold agglutinin antibodies are triggered by an underlying condition, like a viral infection. That’s when CAD is not known to be caused by any other underlying condition. Sometimes CAD might be referred to as primary CAD. To learn more about the science behind CAD, read this page and then watch this video. The average age of onset for CAD is 58 years old, but it has been seen in patients as young as 30. These symptoms may get worse if you have a compromised immune system or an infection, or if you’re exposed to cold temperatures. A bluish color or discomfort of the hands and feet.People living with CAD may experience symptoms like: COLD AGGLUTININ DISEASE What is cold agglutinin disease? What is CAD? Cold agglutinin disease (CAD) is a form of autoimmune hemolytic anemia (AIHA), which means the immune system mistakenly attacks and destroys red blood cells.